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  • KD/KO Validated

DUSP2 Polyclonal antibody

DUSP2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, FC, IHC, ELISA

Conjugate

Unconjugated

Cat no : 27327-1-AP

Synonyms

dual specificity phosphatase 2, DUSP2, PAC 1, PAC1



Tested Applications

Positive WB detected inA549 cells, HeLa cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

27327-1-AP targets DUSP2 in WB, FC, IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen DUSP2 fusion protein Ag25380
Full Name dual specificity phosphatase 2
Calculated Molecular Weight 34 kDa
Observed Molecular Weight 34 kDa
GenBank Accession NumberBC007771
Gene Symbol DUSP2
Gene ID (NCBI) 1844
RRIDAB_2880845
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

DUSP2 belongs to the sub-family of nuclear specific DUSPs that includes DUSP1, 4 and 5. DUSP2 is highly expressed in immune cells, in particular, of patients with inflammatory arthritis, such as in rheumatoid arthritis (RA), and Dusp2 knockout mice present a significant reduction in inflammatory responses. It has been demonstrated that DUSP2 is a downstream target of the tumor suppressor p53 that is required for the cellular response to oxidative stress. DUSP2 is also involved in transcription factor E2F1-mediated apoptotic signaling. Like other members of the DUSP family, DUSP2 interacts with MAPKs; However, the target protein for its phosphatase activity is controversial.

Protocols

Product Specific Protocols
WB protocol for DUSP2 antibody 27327-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Hum Cell

Exosomal hsa_circ_0017252 attenuates the development of gastric cancer via inhibiting macrophage M2 polarization.

Authors - Jin Song
mouseWB

Basic Clin Pharmacol Toxicol

Apatinib combined with Keytruda treatment induces apoptosis of gastric carcinoma cells through CES4/miR-616-5p/DUSP2 axis.

Authors - Fengli Zhang
humanFC

Blood Coagul Fibrinolysis

Effects of Momordica charantia exosomes on platelet activation, adhesion, and aggregation.

Authors - Jianchao Zhang
mouseWB

Bioact Mater

Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity

Authors - Teng Ye
mouseWB

Cell Rep

GABA regulates IL-1β production in macrophages

Authors - Jian Fu
  • KD Validated
humanWB

Aging (Albany NY)

Comprehensive analysis of scRNA-seq and bulk RNA-seq reveal the characteristics of disulfidptosis and a prognostic signature in BLCA

Authors - Hao Deng