DUSP10 Polyclonal antibody, PBS Only

DUSP10 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 30493-1-PBS

Synonyms

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Validation Data Gallery

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  WB analysis using 30493-1-AP (same clone as 30493-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 30493-1-AP (DUSP10 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30493-1-PBS in a different storage buffer formulation.

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Product Information

30493-1-PBS targets DUSP10 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: DUSP10 fusion protein Ag32718
• Full Name: dual specificity phosphatase 10
• Observed Molecular Weight: 53 kDa
• GenBank Accession Number: BC031405
• Gene Symbol: DUSP10
• Gene ID (NCBI): 11221
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

DUSP10, also known as MKP5, is a member of the MKPs subfamily involved in cell proliferation, differentiation, and migration. DUSP10 is a dual specificity phosphatase capable of dephosphorylating both pTyr and pThr residues of activated MAPKs with different affinities. It has been shown that isoforms of the p38 and JNK subfamilies are selectively and more effectively dephosphorylated than ERK subfamily members. DUSP10 has been proposed as a target for therapeutic treatment of atherosclerosis, since DUSP10 inhibition reduces NF-κB-induced TNF-α expression and increases TGF-β1 levels in this disease (PMID: 30939861).