DNAH6 Polyclonal antibody

DNAH6 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, ELISA

Conjugate

Unconjugated

Publications

1

Cat no : 18080-1-AP

Synonyms

Ciliary dynein heavy chain 6, DNAH6, Dnahc6, DNHL1, Dynein heavy chain 6, axonemal, HL 2, HL2, KIAA1697

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Validation Data Gallery

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  IHC staining of mouse brain using 18080-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 18080-1-AP (DNAH6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human small intestine using 18080-1-AP

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 18080-1-AP (DNAH6 antibody) at dilution of 1:200 (under 40x lens).

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  IHC staining of mouse brain using 18080-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 18080-1-AP (DNAH6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human small intestine using 18080-1-AP

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 18080-1-AP (DNAH6 antibody) at dilution of 1:200 (under 10x lens).

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Tested Applications

• Positive IHC detected in: human small intestine tissue, mouse brain tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Immunohistochemistry (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• IHC: See 1 publications below

Product Information

18080-1-AP targets DNAH6 in IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: DNAH6 fusion protein Ag12774
• Full Name: dynein, axonemal, heavy chain 6
• Calculated Molecular Weight: 475 kDa
• GenBank Accession Number: BC104884
• Gene Symbol: DNAH6
• Gene ID (NCBI): 1768
• RRID: AB_2878493
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

DNAH6(Dynein heavy chain 6, axonemal) is also named as DNAHC6, DNHL1, HL2, KIAA1697 and belongs to the dynein heavy chain family.Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains(PMID:8812413). It is a force generating protein of respiratory cilia and produces force towards the minus ends of microtubules.This antibody is specific to DNAH6.

Publications

Species	Application	Title
human,mouse	IHC	Mol Psychiatry; FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors.; Authors - Minjie Shen