DLL1-Specific Polyclonal antibody

• Featured Product
• KD/KO Validated

DLL1-Specific Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

Publications

5

Cat no : 20230-1-AP

Synonyms

Delta, delta like 1 (Drosophila), Delta like protein 1, DELTA1, DL1, DLL1, DLL1-Specific, Drosophila Delta homolog 1, H Delta 1

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Validation Data Gallery

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  WB analysis of human placenta using 20230-1-AP

  human placenta tissue were subjected to SDS PAGE followed by western blot with 20230-1-AP (DLL1-Specific antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse lung using 20230-1-AP

  mouse lung tissue were subjected to SDS PAGE followed by western blot with 20230-1-AP (DLL1-Specific antibody) at dilution of 1:100 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: human placenta tissue, mouse lung tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• KD/KO: See 1 publications below
• WB: See 5 publications below

Product Information

20230-1-AP targets DLL1-Specific in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Cited Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: delta-like 1 (Drosophila)
• Calculated Molecular Weight: 723 aa, 78 kDa
• Observed Molecular Weight: 80 kDa
• GenBank Accession Number: NM_005618
• Gene Symbol: DLL1
• Gene ID (NCBI): 28514
• RRID: AB_10697688
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

DLL1, also named as Delta1, acts as a ligand for Notch receptors. DLL1 blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. The antibody is specific to the protein DLL1.

Publications

Species	Application	Title
human	WB	Cell Rep; Transcriptional control of brain tumor stem cells by a carbohydrate binding protein; Authors - Ahmad Sharanek
human	WB	J Transl Med; MicroRNA-143 acts as a tumor suppressor through Musashi-2/DLL1/Notch1 and Musashi-2/Snail1/MMPs axes in acute myeloid leukemia; Authors - Fanfan Li
human	WB	Int J Cancer; Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.; Authors - Qingmin Yuan
mouse	WB	Sci Rep; MiR-34a-5p promotes multi-chemoresistance of osteosarcoma through down-regulation of the DLL1 gene.; Authors - Youguang Pu ; KD Validated
human	WB	Cell Death Dis; hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.; Authors - Xinxing Wan

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