DLL1 Polyclonal antibody, PBS Only

• 

  WB analysis using 28544-1-AP (same clone as 28544-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 28544-1-AP (DLL1 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28544-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 28544-1-AP (same clone as 28544-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 28544-1-AP (DLL1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28544-1-PBS in a different storage buffer formulation.

DLL1 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 28544-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

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Product Information

28544-1-PBS targets DLL1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: DLL1 fusion protein Ag29534
• Full Name: delta-like 1 (Drosophila)
• Calculated Molecular Weight: 78 kDa
• Observed Molecular Weight: 70 kDa
• GenBank Accession Number: NM_005618
• Gene Symbol: DLL1
• Gene ID (NCBI): 28514
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O00548
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

The Notch pathway functions during diverse developmental and physiological processes. Notch receptor and its ligands, Delta and Jagged, are transmembrane proteins with large extracellular domains that consist primarily of epidermal growth factor (EGF)-like repeats (PMID: 16921404). Delta-like protein 1 (DLL1, also named as Delta1) is a ligand of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain of Notch receptor in a cis and trans fashion manner (PMID: 11006133). DLL1 play a role in development of the central nervous system, somites and lymphocytes (PMID: 31353024). It is overexpressed in various cancers and is involved in the regulation of cancer progression (PMID: 32440154). DLL1 undergoes proteolytic processing in its extracellular domain by ADAM proteases and gamma-secretase (PMID: 17107962; 12794186).