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Connexin-26 Polyclonal antibody, PBS Only

Connexin-26 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 51037-2-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of human brain tissue using Connexin-26 Polyclonal antibody (51037-2-AP)

    WB analysis of human brain using 51037-2-AP (same clone as 51037-2-PBS)

    human brain tissue were subjected to SDS PAGE followed by western blot with 51037-2-AP (Connexin-26 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 51037-2-PBS in a different storage buffer formulation.

Product Information

51037-2-PBS targets Connexin-26 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name gap junction protein, beta 2, 26kDa
Calculated Molecular Weight 26 kDa
Observed Molecular Weight 26 kDa
GenBank Accession NumberBC017048
Gene Symbol Connexin-26
Gene ID (NCBI) 2706
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Connexin-26 (GJB2) is a beta class gap junction protein. Mutations in the gene for connexin-26 are responsible for as much as 50% of pre-lingual, recessive deafness.