Complement factor H Polyclonal antibody, PBS Only
Complement factor H Polyclonal Antibody for WB, IHC, IF/ICC, IF-P, IP, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, IHC, IF/ICC, IF-P, IP, Indirect ELISA
Conjugate
Unconjugated
Cat no : 12748-1-PBS
Synonyms
Validation Data Gallery
Product Information
12748-1-PBS targets Complement factor H in WB, IHC, IF/ICC, IF-P, IP, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Complement factor H fusion protein Ag3482 |
Full Name | complement factor H |
Calculated Molecular Weight | 1231 aa, 139 kDa |
Observed Molecular Weight | 140-150 kDa |
GenBank Accession Number | BC037285 |
Gene Symbol | Complement factor H |
Gene ID (NCBI) | 3075 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Complement factor H (CFH) is an abundant plasma glycoprotein that regulates the function of the alternative complement pathway in the fluid phase and on cellular surfaces (PMID: 2963625). Factor H binds to C3b, accelerates the decay of the alternative pathway C3-convertase (C3bBb), and acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b (PMID: 15163532). It plays a critical role in the homeostasis of the complement system in plasma and in the protection of bystander host cells and tissues from damage by complement activation. Abnormalities in factor H have been associated with renal disease (PMID: 18190458).