Caspase 1 Recombinant antibody, PBS Only

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  IF Staining of mouse liver using 84752-1-RR (same clone as 84752-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse liver tissue using Caspase 1 antibody (84752-1-RR, Clone: 241966A3 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84752-1-PBS in a different storage buffer formulation.

Caspase 1 Uni-rAb^TM Recombinant Antibody for IF-P, Indirect ELISA

Cat No. 84752-1-PBS

Clone No.241966A3

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IF-P, Indirect ELISA

Synonyms

CASP1, Caspase1, Caspase-1, CASP-1, CASP 1

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Product Information

84752-1-PBS targets Caspase 1 in IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Peptide
• Full Name: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
• Calculated Molecular Weight: 404 aa, 45 kDa
• GenBank Accession Number: BC062327
• Gene Symbol: Caspase 1
• Gene ID (NCBI): 834
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: P29466
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020). It has 5 isoforms produced by alternative splicing.