Mouse Caspase 1 Polyclonal antibody, PBS Only

Caspase 1 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 31020-1-PBS

Synonyms

---

Validation Data Gallery

• 

  WB analysis using 31020-1-AP (same clone as 31020-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31020-1-AP (Casp1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31020-1-PBS in a different storage buffer formulation.

---

Product Information

31020-1-PBS targets Caspase 1 in WB, Indirect ELISA applications and shows reactivity with mouse, rat samples.

• Tested Reactivity: mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Caspase 1 fusion protein Ag34441
• Full Name: caspase 1
• Observed Molecular Weight: 35-40 kDa
• GenBank Accession Number: BC008152
• Gene Symbol: Caspase 1
• Gene ID (NCBI): 12362
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020). 31020-1-AP is designed for mouse caspase 1.