Anti-Human CXCL10/IP-10 Rabbit Recombinant Antibody, PBS Only

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  FC experiment of human PBMCs using 98265-1-RR (same clone as 98265-1-PBS)

  1x10^6 untreated or IFN gamma and brefeldin A treated human PBMCs were intracellularly stained with 0.25 ug Anti-Human CXCL10/IP-10 Rabbit Recombinant Antibody (98265-1-RR, Clone: 242013E12) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98265-1-PBS in a different storage buffer formulation.

CXCL10/IP-10 Uni-rAb^TM Recombinant Antibody for FC (Intra)

Cat No. 98265-1-PBS

Clone No.242013E12

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC (Intra)

Synonyms

CXCL10, CXCL10/IP10, IP10, CXCL 10, C-X-C motif chemokine 10

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Product Information

98265-1-PBS targets CXCL10/IP-10 in FC (Intra) applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: chemokine (C-X-C motif) ligand 10
• Calculated Molecular Weight: 11 kDa
• GenBank Accession Number: BC010954
• Gene Symbol: CXCL10
• Gene ID (NCBI): 3627
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: P02778
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

CXCL10 (also known as IP-10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects. CXCL10 is a 12-kDa protein and constitutes two internal disulfide cross bridges. The predicted signal peptidase cleavage generates a 10-kDa secreted polypeptide with four conserved cysteine residues in the N-terminal. The CXCL10 gene localizes on chromosome 4 at band q21, a locus associated with an acute monocytic/B-lymphocyte lineage leukemia exhibiting translocation of t (4; 11) (q21; q23). CXCL10 mediates leukocyte trafficking, adaptive immunity, inflammation, haematopoiesis and angiogenesis. Under proinflammatory conditions CXCL10 is secreted from a variety of cells, such as leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, stromal cells (fibroblasts) and keratinocytes in response to IFN-γ.