COL6A3 Polyclonal antibody, PBS Only

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  IHC staining of human cervical cancer using 19798-1-AP (same clone as 19798-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 19798-1-AP (Collagen Type VI antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19798-1-PBS in a different storage buffer formulation.

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  IHC staining of human lung cancer using 19798-1-AP (same clone as 19798-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 19798-1-AP (Collagen Type VI antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19798-1-PBS in a different storage buffer formulation.

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  IHC staining of human urothelial carcinoma using 19798-1-AP (same clone as 19798-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human urothelial carcinoma tissue slide using 19798-1-AP (Collagen Type VI antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19798-1-PBS in a different storage buffer formulation.

COL6A3 Polyclonal Antibody for IHC, Indirect ELISA

Cat No. 19798-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, Indirect ELISA

Synonyms

Collagen alpha 3(VI) chain, Collagen alpha-3(VI) chain, Collagen Type VI

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Product Information

19798-1-PBS targets COL6A3 in IHC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: collagen, type VI, alpha 3
• Calculated Molecular Weight: 344 kDa
• Observed Molecular Weight: 300 kDa
• GenBank Accession Number: NM_004369
• Gene Symbol: COL6A3
• Gene ID (NCBI): 1293
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P12111
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

COL6A3 belongs to the type VI collagen family. Collagen VI acts as a cell-binding protein. It is expected to be expressed in smooth muscle. And the calculated molecular weight of COL6A3 is 343 kDa. The protein has similar expression in obese and T2DM (2 patients, and it regulates the chemotaxis and inflammation of macrophages in adipose tissue. Its expression is also related to weight gain. The expression of this protein in adipocytes is related to insulin resistance, which is believed to depend on PPAR (peroxisome proliferator-activated receptor) α-mediated adipocyte development (PMID: 25337653). Defects in COL6A3 are a cause of Bethlem myopathy (BM). Defects in COL6A3 are a cause of Ullrich congenital muscular dystrophy (UCMD) which also known as Ullrich scleroatonic muscular dystrophy. This antibody is specific to COL6A3.