COL4A5 Polyclonal antibody

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COL4A5 Polyclonal Antibody for ELISA

Cat No. 19797-1-AP

Publications(16)

Host / Isotype

Rabbit / IgG

Reactivity

human and More (2)

Applications

WB, IHC, IF, ELISA

Synonyms

Collagen alpha 5(IV) chain, Collagen alpha-5(IV) chain

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Published Applications

• WB: See 12 publications below
• IHC: See 2 publications below
• IF: See 4 publications below

Product Information

19797-1-AP targets COL4A5 in WB, IHC, IF, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: collagen, type IV, alpha 5
• Calculated Molecular Weight: 161 kDa
• GenBank Accession Number: NM_000495
• Gene Symbol: COL4A5
• Gene ID (NCBI): 1287
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P29400
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

COL4A5 belongs to the type IV collagen family. Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A5 are the cause of Alport syndrome X-linked (APSX). Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are the cause of diffuse leiomyomatosis with Alport syndrome (DL-ATS)which also known as esophageal and vulval leiomyomatosis with nephropathy or Alport syndrome and diffuse leiomyomatosis (ATS-DL).

Publications

Species	Application	Title
mouse	IF	Biomaterials; A novel bioscaffold with naturally-occurring extracellular matrix promotes hepatocyte survival and vessel patency in mouse models of heterologous transplantation.; Authors - Wei Yang
mouse	WB	PLoS Genet; Minor Type IV Collagen α5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1.; Authors - Qian Xiao
human	WB	FASEB J; Drastic induction of MMP-7 by cortisol in the human amnion: implications for membrane rupture at parturition.; Authors - Lu-Yao Wang
mouse	WB	Bioorg Chem; AT1, a small molecular degrader of BRD4 based on proteolysis targeting chimera technology alleviates renal fibrosis and inflammation in diabetic nephropathy; Authors - Meng Yang
mouse	IF	Sci Rep; Methanol fixed fibroblasts serve as feeder cells to maintain stem cells in the pluripotent state in vitro.; Authors - Yahui Ren
mouse	WB	Front Pharmacol; Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis via the NF-κB signaling pathway; Authors - Zhe Wang