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CLUH Recombinant antibody, PBS Only

CLUH Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241640C1

Cat no : 84321-3-PBS

Synonyms

KIAA0664, Protein KIAA0664, FLJ23672, CLU1, 241640C1

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CLUH Recombinant antibody (84321-3-RR)

    WB analysis using 84321-3-RR (same clone as 84321-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84321-3-RR (CLUH antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84321-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84321-3-RR

    Affinity and Kinetic Characterization of 84321-3-RR

    Biolayer interferometry (BLl) kinetic assays of 84321-3-RR against Human CLUH were performed. The affinity constant is below 1 pM.

Product Information

84321-3-PBS targets CLUH in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen CLUH fusion protein Ag34275
Full Name KIAA0664
Observed Molecular Weight147-150 kDa
GenBank Accession NumberBC156940
Gene Symbol CLUH
Gene ID (NCBI) 23277
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Clustered mitochondria homolog (CLUH) is a conserved RNA-binding protein, that binds transcripts encoding proteins involved in the respiratory chain, the tricarboxylic acid (TCA) cycle, and other mitochondrial metabolic pathways. Upon loss of CLUH, target mRNAs are subjected to faster decay, and their respective proteins are decreased in abundance. This leads to alterations in mitochondrial distribution (mitochondrial clustering as the gene name alludes to) mitochondrial cristae integrity, respiratory defects, loss of mtDNA, and decreased activity of TCA cycle enzymes. (PMID: 35559794)