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CLSTN3 Recombinant antibody, PBS Only

CLSTN3 Uni-rAbTM Recombinant Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

240865C10

Cat no : 83931-1-PBS

Synonyms

Alc-beta, alcbeta, Alcadein-beta, Alcadein beta, Alc beta

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CLSTN3 Recombinant antibody (83931-1-RR)

    WB analysis using 83931-1-RR (same clone as 83931-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83931-1-RR (CLSTN3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83931-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83931-1-RR

    Affinity and Kinetic Characterization of 83931-1-RR

    Biolayer interferometry (BLl) kinetic assays of 83931-1-RR against Human CLSTN3 were performed. The affinity constant is 1.51 nM.

Product Information

The immunogen of 83931-1-PBS is CLSTN3 Fusion Protein expressed in E. coli.

Tested Reactivity human, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen CLSTN3 fusion protein Ag14897
Full Name calsyntenin 3
Calculated Molecular Weight 968 aa, 107 kDa
GenBank Accession NumberBC039075
Gene Symbol CLSTN3
Gene ID (NCBI) 9746
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Calsyntenins, also called alcadeins, are cadherin superfamily proteins first identified as synaptic proteins (PMID: 11161476; 12498782). Calsyntenins are type I transmembrane proteins with extracellular domains containing two cadherin repeats and an LNS (laminin, neurexin, sex hormone-binding globulin) domain (PMID: 24613359). Calsyntenin-3 (CLSTN3, also known as alcadein-beta) is a synapse-organizing protein that promotes the development of synapses. It is a postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (PMID: 25352602; 24613359).