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CLEC2D Polyclonal antibody, PBS Only

CLEC2D Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 13188-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CLEC2D Polyclonal antibody (13188-1-AP)

    WB analysis using 13188-1-AP (same clone as 13188-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13188-1-AP (CLEC2D antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13188-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of Jurkat cells using CLEC2D Polyclonal antibody (13188-1-AP)

    WB analysis of Jurkat using 13188-1-AP (same clone as 13188-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 13188-1-AP (CLEC2D antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13188-1-PBS in a different storage buffer formulation.

Product Information

13188-1-PBS targets CLEC2D in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen CLEC2D fusion protein Ag3862
Full Name C-type lectin domain family 2, member D
Calculated Molecular Weight 154 aa, 18 kDa
Observed Molecular Weight 33 kDa
GenBank Accession NumberBC019883
Gene Symbol CLEC2D
Gene ID (NCBI) 29121
RRIDAB_2877920
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CLEC2D (C-type lectin domain family 2 member D), also known as LLT1 (lectin-like transcript 1) or OCIL (Osteoclast inhibitory lectin), is a single-pass type II membrane protein expressed by hematopoietic cells and osteoblasts (PMID: 21930700; 14753741). Its expression was found to be tightly correlated with activation on T cells, NK cells, B cells, and DCs (PMID: 21930700). CLEC2D is a ligand for the human NKR-P1A (CD161) receptor and their interaction differentially regulates NK- and T-cell functions (PMID: 16339513, 16339512). It inhibits the formation and function of osteoclasts and modulates the release of interferon-gamma by human NK cells (PMID:14753741; 20415786).