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CLEC2D Polyclonal antibody, PBS Only

CLEC2D Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 13188-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CLEC2D Polyclonal antibody (13188-1-AP)

    WB analysis using 13188-1-AP (same clone as 13188-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13188-1-AP (CLEC2D antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13188-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of Jurkat cells using CLEC2D Polyclonal antibody (13188-1-AP)

    WB analysis of Jurkat using 13188-1-AP (same clone as 13188-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 13188-1-AP (CLEC2D antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13188-1-PBS in a different storage buffer formulation.

Product Information

13188-1-PBS targets CLEC2D in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen CLEC2D fusion protein Ag3862
Full Name C-type lectin domain family 2, member D
Calculated Molecular Weight 154 aa, 18 kDa
Observed Molecular Weight 33 kDa
GenBank Accession NumberBC019883
Gene Symbol CLEC2D
Gene ID (NCBI) 29121
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CLEC2D (C-type lectin domain family 2 member D), also known as LLT1 (lectin-like transcript 1) or OCIL (Osteoclast inhibitory lectin), is a single-pass type II membrane protein expressed by hematopoietic cells and osteoblasts (PMID: 21930700; 14753741). Its expression was found to be tightly correlated with activation on T cells, NK cells, B cells, and DCs (PMID: 21930700). CLEC2D is a ligand for the human NKR-P1A (CD161) receptor and their interaction differentially regulates NK- and T-cell functions (PMID: 16339513, 16339512). It inhibits the formation and function of osteoclasts and modulates the release of interferon-gamma by human NK cells (PMID:14753741; 20415786).