CLCC1 Monoclonal antibody, PBS Only

CLCC1 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 68853-7-PBS
Clone No.3C4B4

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, Indirect ELISA

Mid-1-related chloride channel protein 1, MCLC, KIAA0761, Chloride channel CLIC-like protein 1, chloride channel CLIC like 1

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Product Information

68853-7-PBS targets CLCC1 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen CLCC1 fusion protein Ag24682 Predict reactive species
Full Name chloride channel CLIC-like 1
Calculated Molecular Weight 551 aa, 62 kDa
Observed Molecular Weight 50-60 kDa
GenBank Accession NumberBC002939
Gene Symbol CLCC1
Gene ID (NCBI) 23155
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ96S66
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CLCC1, also known as MCLC, is a transmembrane protein that localizes to intracellular compartments, including endoplasmic reticulum (ER), and it functions as a chloride channel (PMID: 11279057). It has been shown that loss of CLCC1 results in ER Stress, misfolded protein accumulation, and neurodegeneration (PMID: 25698737). CLCC1 forms homomultimer in the ER membrane and is a pore-forming component of an anion channel. Studies found that disruption of ER ion homeostasis maintained by CLCC1 is one of the causes of neurodegenerative diseases, such as ALS (amyotrophic lateral sclerosis) (PMID: 37142673).

Loading...