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CLCC1 Monoclonal antibody, PBS Only

CLCC1 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3C4B4

Cat no : 68853-7-PBS

Synonyms

Mid-1-related chloride channel protein 1, MCLC, KIAA0761, Chloride channel CLIC-like protein 1, chloride channel CLIC like 1

Validation Data Gallery

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  • Western Blot (WB) analysis of hTERT-RPE1 cells using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis of hTERT-RPE1 using 68853-7-Ig (same clone as 68853-7-PBS)

    hTERT-RPE1 cells were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of COLO 320 cells using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis of COLO 320 using 68853-7-Ig (same clone as 68853-7-PBS)

    COLO 320 cells were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis using 68853-7-Ig (same clone as 68853-7-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis using 68853-7-Ig (same clone as 68853-7-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

Product Information

68853-7-PBS targets CLCC1 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen CLCC1 fusion protein Ag24682
Full Name chloride channel CLIC-like 1
Calculated Molecular Weight 551 aa, 62 kDa
Observed Molecular Weight 50-60 kDa
GenBank Accession NumberBC002939
Gene Symbol CLCC1
Gene ID (NCBI) 23155
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CLCC1, also known as MCLC, is a transmembrane protein that localizes to intracellular compartments, including endoplasmic reticulum (ER), and it functions as a chloride channel (PMID: 11279057). It has been shown that loss of CLCC1 results in ER Stress, misfolded protein accumulation, and neurodegeneration (PMID: 25698737). CLCC1 forms homomultimer in the ER membrane and is a pore-forming component of an anion channel. Studies found that disruption of ER ion homeostasis maintained by CLCC1 is one of the causes of neurodegenerative diseases, such as ALS (amyotrophic lateral sclerosis) (PMID: 37142673).