Product Information
68853-7-PBS targets CLCC1 in WB, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | CLCC1 fusion protein Ag24682 Predict reactive species |
Full Name | chloride channel CLIC-like 1 |
Calculated Molecular Weight | 551 aa, 62 kDa |
Observed Molecular Weight | 50-60 kDa |
GenBank Accession Number | BC002939 |
Gene Symbol | CLCC1 |
Gene ID (NCBI) | 23155 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | Q96S66 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
CLCC1, also known as MCLC, is a transmembrane protein that localizes to intracellular compartments, including endoplasmic reticulum (ER), and it functions as a chloride channel (PMID: 11279057). It has been shown that loss of CLCC1 results in ER Stress, misfolded protein accumulation, and neurodegeneration (PMID: 25698737). CLCC1 forms homomultimer in the ER membrane and is a pore-forming component of an anion channel. Studies found that disruption of ER ion homeostasis maintained by CLCC1 is one of the causes of neurodegenerative diseases, such as ALS (amyotrophic lateral sclerosis) (PMID: 37142673).