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  • Western Blot (WB) analysis of various lysates using CHRM3 Polyclonal antibody (21978-1-AP)

    WB analysis using 21978-1-AP (same clone as 21978-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21978-1-AP (CHRM3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21978-1-PBS in a different storage buffer formulation.

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Product Information

21978-1-PBS targets CHRM3 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen CHRM3 fusion protein Ag17791 Predict reactive species
Full Name cholinergic receptor, muscarinic 3
Calculated Molecular Weight 590 aa, 66 kDa
Observed Molecular Weight60-66 kDa
GenBank Accession NumberBC121026
Gene Symbol CHRM3
Gene ID (NCBI) 1131
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP20309
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CHRM3 (M3 muscarinic acetylcholine receptor) is a major player in many kinds of cancer (PMID: 26175851). The expression of muscarinic receptors, mainly the CHRM3, is amplified in several types of tumors, including colon cancer, prostate cancer, endometrial carcinoma, and gastric cancer. Colon cancer overexpresses CHRM3, and post-M3R signaling promotes cell growth via the activation of the epidermal growth factor receptors/ERK and protein kinase C/p38 mitogen-activated protein kinase (MAPK) signaling pathways (PMID: 37744266).