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CHD4 Monoclonal antibody, PBS Only

CHD4 Monoclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 66222-1-PBS
Clone No.3D9G2

Host / Isotype

Mouse / IgG1

Reactivity

human, mouse, rat

Applications

WB, IHC, IF/ICC, Indirect ELISA

ATP dependent helicase CHD4, CHD 4, CHD4, Mi 2b, Mi2 BETA

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

66222-1-PBS targets CHD4 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen CHD4 fusion protein Ag5729 Predict reactive species
Full Name chromodomain helicase DNA binding protein 4
Calculated Molecular Weight 1937 aa, 221 kDa
Observed Molecular Weight 260 kDa
GenBank Accession NumberBC038596
Gene Symbol CHD4
Gene ID (NCBI) 1108
RRIDAB_2881613
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ14839
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Chromodomain helicase DNA-binding protein 4 (CHD4) is an ATP dependent chromatin remodeler and a major subunit of the repressive NuRD complex [PMID:9790534]. This complex plays key roles in transcriptional regulation and reorganization and maintenance of chromatin structure, as it targets pericentromeric heterochromatin and has recently been implicated in DNA damage repair, being rapidly recruited to DNA double strand breaks [PMID:17694084]. CHD4 is a novel BRIT1 binding partner that regulates the HR repair process, which is a critical pathway of repairing DNA double strand breaks and plays an essential role in maintaining genomic integrity [PMID:22219182]. The calcualted molecular weight of CHD4 is 218 kDa, but modified CHD4 is about 250-280 kDa.

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