CENPF Recombinant antibody, PBS Only

CENPF Uni-rAbTM Recombinant Antibody for IF/ICC, Indirect ELISA
Cat No. 84865-4-PBS
Clone No.242277G9

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, Indirect ELISA

PRO1779, CENP-F, CENF, 242277G9

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

84865-4-PBS targets CENPF in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen CENPF fusion protein Ag29665 Predict reactive species
Full Name centromere protein F, 350/400ka (mitosin)
Calculated Molecular Weight 368 kDa
GenBank Accession NumberNM_016343
Gene Symbol CENPF
Gene ID (NCBI) 1063
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP49454
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CENPF, also named as mitosin and centromere protein F (PMID: 22912832), belongs to centromere protein F family. During the cell cycle, CENPF localizes in multiple cellular structures including the nuclear envelope in late G2/early prophase and kinetochores throughout mitosis (PMID: 30198378). CENPF is required for kinetochore function and chromosome segregation in mitosis and required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1 (PMID: 17600710)(PMID: 7542657). It regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation (PMID: 26125848). The calculated molecular weight of CENPF is ~358 kDa and CENPF can be detected as ~367 kDa (PMID: 7542657).

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