Product Information
66912-1-PBS targets CDC25C in Indirect ELISA, WB applications and shows reactivity with rat, mouse, human samples.
Tested Reactivity | rat, mouse, human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | CDC25C fusion protein Ag10240 Predict reactive species |
Full Name | cell division cycle 25 homolog C (S. pombe) |
Calculated Molecular Weight | 473 aa, 53 kDa |
Observed Molecular Weight | 46-53 kDa |
GenBank Accession Number | BC019089 |
Gene Symbol | CDC25C |
Gene ID (NCBI) | 995 |
RRID | AB_2882239 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P30307 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
The cell division cycle 25 (CDC25) family of proteins are highly conserved dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. CDC25C (cell division cycle 25 homolog C) is one of the 3 isoforms of CDC25 in mammalian cells. It is present in the cytoplasm of asynchronously growing human cells (PMID:10330186). And it may be phosphorylated by its own substrate, an active cdc2-cyclin B complex, to create an autoactivation loop (PMID:7937793). It can be hyperphosphorylated to get the active form of 70 kDa (PMID:18296513). CDC25C has some isofroms with molecular mass of 46-53 kDa.