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CD89 Recombinant antibody, PBS Only

CD89 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241426H1

Cat no : 84384-5-PBS

Synonyms

IgA Fc receptor, FCAR, 241426H1

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CD89 Recombinant antibody (84384-5-RR)

    WB analysis using 84384-5-RR (same clone as 84384-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84384-5-RR (CD89 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84384-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84384-5-RR

    Affinity and Kinetic Characterization of 84384-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84384-5-RR against Human CD89 were performed. The affinity constant is 13.5 nM.

Product Information

84384-5-PBS targets CD89 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant Protein
Full Name Fc fragment of IgA, receptor for
Calculated Molecular Weight 287 aa, 32 kDa
Observed Molecular Weight65-70 kDa
GenBank Accession NumberBC027953
Gene Symbol CD89
Gene ID (NCBI) 2204
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

FcαRI (CD89) is a member of the Fc receptor immunoglobulin superfamily, constitutively expressed on cells of the myeloid lineage like neutrophils, eosinophils, monocytes macrophages, and platelets (PMID: 28103138). CD89 expression and activation are increased in human blood phagocytes following bacterial infection, together with increased expression and association of FcRγ with CD89 (PMID: 34756952). CD89 binds both subclasses of IgA (IgA1 and IgA2) with moderate affinity, but also binds other molecules such as TfR1, C-reactive protein and bacterial ligands. CD89 represents an effective target molecule for immunotherapy mediated by bispecific antibodies (PMID: 37081893).