Anti-Mouse CD83 Rabbit Recombinant Antibody, PBS Only

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  FC experiment of mouse splenocytes using 98119-1-RR (same clone as 98119-1-PBS)

  1x10^6 untreated or LPS-treated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD83 Rabbit Recombinant Antibody (98119-1-RR, Clone: 241002B7) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98119-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse splenocytes using 98119-1-RR (same clone as 98119-1-PBS)

  1x10^6 LPS-treated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD83 Rabbit Recombinant Antibody (98119-1-RR, Clone: 241002B7) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD83 Rabbit Recombinant Antibody (98119-1-RR, Clone: 241002B7) (black, dashed), and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98119-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98119-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98119-1-RR against Mouse CD83 were performed. The affinity constant is below 1 pM.

CD83 {ptg:Brand} Recombinant Antibody for FC

Cat No. 98119-1-PBS

Clone No.241002B7

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Synonyms

mCD83, CD83 antigen, 241002B7

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Product Information

98119-1-PBS targets CD83 in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Fusion Protein
• Full Name: CD83 antigen
• Calculated Molecular Weight: 21 kDa
• GenBank Accession Number: NM_009856.3
• Gene Symbol: Cd83
• Gene ID (NCBI): 12522
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: O88324
• Storage Buffer: PBS only , pH 7.3
• Storage Conditions: Store at -80°C.

Background Information

CD83 is a member of the immunoglobulin (Ig) superfamily, consisting of an extracellular V-type Ig-like domain, a transmembrane domain, and a cytoplasmic tail. CD83 is one of the most prominent markers for fully matured dendritic cells (DCs) (PMID: 17334966). It is also found on the surface of other activated hematopoietic cells, including lymphocytes, monocytes, macrophages, and neutrophils (PMID: 31231400; 17334966). CD83 regulates the maturation, activation, and homeostasis of numerous immune cells (PMID: 31231400; 32362900). CD83 can also expressed as a soluble form. Soluble CD83 can bind to DCs and inhibit their maturation (PMID: 17334966; 12403928).