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CD6 Recombinant antibody, PBS Only

CD6 Uni-rAbTM Recombinant Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241965D11

Cat no : 84508-5-PBS

Synonyms

TP120, T-cell differentiation antigen CD6, T12, Soluble CD6, CD6 molecule

Validation Data Gallery

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  • Western Blot (WB) analysis of Jurkat cells using CD6 Recombinant antibody (84508-5-RR)

    WB analysis of Jurkat using 84508-5-RR (same clone as 84508-5-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 84508-5-RR (CD6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84508-5-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using CD6 Recombinant antibody (84508-5-RR)

    IHC staining of human tonsillitis using 84508-5-RR (same clone as 84508-5-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 84508-5-RR (CD6 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84508-5-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using CD6 Recombinant antibody (84508-5-RR)

    IHC staining of human tonsillitis using 84508-5-RR (same clone as 84508-5-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 84508-5-RR (CD6 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84508-5-PBS in a different storage buffer formulation.

Product Information

84508-5-PBS targets CD6 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen FusionProtein
Full Name CD6 molecule
Observed Molecular Weight140 kDa
GenBank Accession NumberBC033755
Gene Symbol CD6
Gene ID (NCBI) 923
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CD6 is a type I transmembrane glycoprotein that belongs to the scavenger receptor cysteine-rich superfamily (PMID: 21880988). It is composed of an extracellular region, which consists of three tandem SRCR domains, a transmembrane region, and a cytoplasmic tail devoid of intrinsic catalytic activity but harboring several phosphorylatable residues suitable for intracellular signal transduction (PMID: 38139340; 23711376). CD6 is expressed by T cells, medullary thymocytes, a subset of B cells and NK cells, and in some cells of the brain (PMID: 1919444; 21178331). CD6 plays a role in lymphocyte activation, proliferation, and survival processes via interaction with its endogenous ligands.