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CD6 Recombinant antibody, PBS Only (Capture)

CD6 Uni-rAbTM Recombinant Antibody for IF/ICC, Cytometric bead array, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241965G2

Cat no : 84508-4-PBS

Synonyms

TP120, T-cell differentiation antigen CD6, T12, Soluble CD6, CD6 molecule

Validation Data Gallery

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  • Immunofluorescence (IF) / fluorescent staining of MOLT-4 cells using CD6 Recombinant antibody (84508-4-RR)

    IF Staining of MOLT-4 using 84508-4-RR (same clone as 84508-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed MOLT-4 cells using CD6 antibody (84508-4-RR, Clone: 241965G2 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84508-4-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP01358-1

    Cytometric bead array standard curve of MP01358-1

    Cytometric bead array standard curve of MP01358-1, CD6 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 84508-4-PBS. Detection antibody: 84508-3-PBS. Standard: Eg2079. Range: 0.781-100 ng/mL.

Product Information

84508-4-PBS targets CD6 as part of a matched antibody pair:

MP01358-1: 84508-4-PBS capture and 84508-3-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein
Full Name CD6 molecule
GenBank Accession NumberBC033755
Gene Symbol CD6
Gene ID (NCBI) 923
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CD6 is a type I transmembrane glycoprotein of 105-130 kDa that belongs to the scavenger receptor cysteine-rich superfamily (PMID: 21880988). It is composed of an extracellular region, which consists of three tandem SRCR domains, a transmembrane region, and a cytoplasmic tail devoid of intrinsic catalytic activity but harbouring several phosphorylatable residues suitable for intracellular signal transduction (PMID: 38139340; 23711376). CD6 is expressed by T cells, medullary thymocytes, a subset of B cells and NK cells, and in some cells of the brain (PMID: 1919444; 21178331). CD6 plays a role in lymphocyte activation, proliferation, and survival processes via interaction with its endogenous ligands.