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Anti-Human CD49b (AK7) Mouse IgG2a Recombinant Antibody, PBS Only

CD49b Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

AK7

Cat no : 65583-1-PBS

Synonyms

ITGA2, Integrin alpha 2, GPIa, Collagen receptor, BR

Validation Data Gallery

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  • Flow cytometry (FC) experiment of human peripheral blood platelets using Anti-Human CD49b (AK7) Mouse IgG2a Recombinant Ant (65583-1-MR)

    FC experiment of human peripheral blood platelets using 65583-1-MR (same clone as 65583-1-PBS)

    1x10^6 human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD49b (AK7) Mouse IgG2a Recombinant Antibody (65583-1-MR, Clone: AK7) (red) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) (blue), and PE-conjugated Goat Anti-Mouse IgG. Cells were not fixed. This data was developed using the same antibody clone with 65583-1-PBS in a different storage buffer formulation.

Product Information

65583-1-PBS targets CD49b in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG2a
Class Recombinant
Type Antibody
Immunogen Human platelets
Full Name integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Calculated Molecular Weight 126 kDa
GenBank Accession NumberNM_002203
Gene Symbol Integrin alpha 2
Gene ID (NCBI) 3673
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CD49b, also known as alpha2 integrin, is a type I transmembrane glycoprotein which forms an adhesion molecule VLA-2 with beta1 integrin. CD49b is a receptor for many (extracellular) matrix and non-matrix molecules (PMID: 23847623). CD49b is expressed on numerous cell types including platelets, activated T cells, B cells, and monocytes. CD49b activation skews NK cell effector function to a phenotype that exhibits elevated IFN-γ production with a concomitant inhibition of motility and cytolytic function (PMID: 32971468, 32762681). The Anti-Human CD49b antibody, clone AK7, is derived from Human platelets.