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CD122/IL-2RB Recombinant antibody, PBS Only

CD122/IL-2RB Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241677C9

Cat no : 84389-2-PBS

Synonyms

IL2RB, IL 2RB, IL 2R subunit beta, IL 2 receptor subunit beta, High affinity IL-2 receptor subunit beta

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CD122/IL-2RB Recombinant antibody (84389-2-RR)

    WB analysis using 84389-2-RR (same clone as 84389-2-PBS)

    NK-92 cells were subjected to SDS PAGE followed by western blot with 84389-2-RR (CD122/IL-2RB antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84389-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84389-2-RR

    Affinity and Kinetic Characterization of 84389-2-RR

    Biolayer interferometry (BLl) kinetic assays of 84389-2-RR against Human CD122/IL-2RB were performed. The affinity constant is 32.2 nM.

Product Information

84389-2-PBS targets CD122/IL-2RB in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant Protein
Full Name interleukin 2 receptor, beta
Calculated Molecular Weight 551 aa, 61 kDa
Observed Molecular Weight70 kDa
GenBank Accession NumberBC025691
Gene Symbol IL2RB
Gene ID (NCBI) 3560
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. The beta subunit (IL2RB, also known as CD122 and p75) is involved in receptor mediated endocytosis and transduces the mitogenic signals of nterleukin 2.