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CCL4/MIP-1 beta Polyclonal antibody, PBS Only

CCL4/MIP-1 beta Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 22352-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CCL4/MIP-1 beta Polyclonal antibody (22352-1-AP)

    WB analysis using 22352-1-AP (same clone as 22352-1-PBS)

    Untreated, PMA, LPS, and Brefeldin A treated THP-1 cells were subjected to SDS PAGE followed by western blot with 22352-1-AP (CCL4/MIP-1 beta antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22352-1-PBS in a different storage buffer formulation.

Product Information

22352-1-PBS targets CCL4/MIP-1 beta in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen CCL4/MIP-1 beta fusion protein Ag17928
Full Name chemokine (C-C motif) ligand 4
Calculated Molecular Weight 92 aa, 10 kDa
Observed Molecular Weight11 kDa
GenBank Accession NumberBC107433
Gene Symbol CCL4/MIP-1 beta
Gene ID (NCBI) 6351
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β), is a CC chemokine with specificity for CCR5 receptors, and is one of the major HIV-suppressive factors produced by CD8+ T-cells. MIP-1β is an acidic protein composed of 69 amino acids that is produced by many cells, particularly macrophages, dendritic cells, and lymphocytes. MIP-1β is responsible for the activation of PMN and is involved in acute neutrophilic inflammation. Recombinant MIP-1β induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).