CCDC23 Recombinant antibody

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  IF Staining of U2OS using 82998-4-RR

  Immunofluorescent analysis of (4% PFA) fixed U2OS cells using CCDC23 antibody (82998-4-RR, Clone: 230175B2 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1).CL594-Phalloidin (red).

• 

  IF Staining of U2OS using 82998-4-RR

  Immunofluorescent analysis of (4% PFA) fixed U2OS cells using CCDC23 antibody (82998-4-RR, Clone: 230175B2 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1).CL594-Phalloidin (red).

CCDC23 {ptg:Brand} Recombinant Antibody for IF/ICC, ELISA

Cat No. 82998-4-RR

Clone No.230175B2

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

IF/ICC, ELISA

Synonyms

CCDC23, SVBP

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Tested Applications

• Positive IF/ICC detected in: U2OS cells

Recommended dilution

• Immunofluorescence (IF)/ICC: IF/ICC : 1:200-1:800

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

82998-4-RR targets CCDC23 in IF/ICC, ELISA applications and shows reactivity with Human samples.

• Tested Reactivity: Human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: CCDC23 fusion protein Ag33650
• Full Name: coiled-coil domain containing 23
• GenBank Accession Number: BC029427
• Gene Symbol: CCDC23
• Gene ID (NCBI): 374969
• RRID: AB_3670745
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q8N300
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

CCDC23 also known as SVBP is a small vasohibin-binding protein of 66 amino acids, and functions as a chaperone of VASH1 in vascular endothelial cells(PMID: 20736312). SVBP enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin(PMID: 29146869, 31171830). Mutations in SVBP cause Neurodevelopmental disorders with ataxia, hypotonia, and microcephaly (NEDAHM)(PMID: 30607023, 31363758).