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CASP14 Polyclonal antibody, PBS Only

CASP14 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 28136-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CASP14 Polyclonal antibody (28136-1-AP)

    WB analysis using 28136-1-AP (same clone as 28136-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28136-1-AP (CASP14 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28136-1-PBS in a different storage buffer formulation.

Product Information

28136-1-PBS targets CASP14 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen CASP14 fusion protein Ag27242
Full Name caspase 14, apoptosis-related cysteine peptidase
Calculated Molecular Weight 242 aa, 28 kDa
Observed Molecular Weight35 kDa
GenBank Accession NumberBC069541
Gene Symbol CASP14
Gene ID (NCBI) 23581
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Caspase14 belongs to the caspase family of cysteinyl aspartate-specific proteinases that frequently play a central role in apoptosis. Caspase14 exist as inactive proenzymes that undergo proteolytic processing to produce large and small subunits (p20 and p10) at Ile152/Lys153 residues, which is different to other caspases (Asp residue). Caspase14 plays a role in protein maturation of filaggrin, and possibly in DNA repair. Overexpression of Caspase14 has been detected in several of epithelial malignancies, indicating that Caspase14 could play a role in carcinogenesis and disease progression of cancers. Caspase14 can binds the apoptosis-inducing factor (AIF) indicating that caspase14 may be an anti-apoptotic protein. In the LADC specimens, two bands can be detected with MW of 35 kDa and 37 kDa which represent Caspase14 and the phosphorylated Caspase14(pCasp-14) respectively. (PMID:21567094, 12200134, 10203698, 17515931, 16061209). This antibody can recognise all the forms of Caspase14.