C9 Polyclonal antibody, PBS Only

• 

  WB analysis of human plasma using 25891-1-AP (same clone as 25891-1-PBS)

  human plasma were subjected to SDS PAGE followed by western blot with 25891-1-AP (C9 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25891-1-PBS in a different storage buffer formulation.

C9 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 25891-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

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Product Information

25891-1-PBS targets C9 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: C9 fusion protein Ag23137
• Full Name: complement component 9
• Calculated Molecular Weight: 559 aa, 63 kDa
• Observed Molecular Weight: 64 kDa
• GenBank Accession Number: BC020721
• Gene Symbol: C9
• Gene ID (NCBI): 735
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P02748
• Storage Buffer: PBS Only
• Storage Conditions: Store at -80°C.

Background Information

The final consequence of complement activation is the formation of the membrane attack complex (MAC), a multiprotein assembly that perforates cell membranes, forming transmembrane channels. The MAC plays a critical role in complement-mediated hemolysis and inflammasome activation (PMID: 27444648). Complement component 9 (C9) is 1 of 5 late-acting proteins of complement that participate in the assembly and function of the MAC. C9 may be cleaved by thrombin to generate fragments C9a (25 kDa) and C9b (37 kDa) (PMID: 7523406).