Bestrophin-1 Polyclonal antibody
Bestrophin-1 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
ELISA
Conjugate
Unconjugated
Cat no : 55012-1-AP
Synonyms
Validation Data Gallery
Product Information
55012-1-AP targets Bestrophin-1 in ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide |
| Full Name | bestrophin 1 |
| Calculated Molecular Weight | 69 kDa |
| GenBank Accession Number | NM_004183 |
| Gene Symbol | Bestrophin/BEST1 |
| Gene ID (NCBI) | 7439 |
| RRID | AB_2881256 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | 0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Bestrophin-1 (BEST1) is a 68 kDa transmembrane protein which belongs to the bestrophin family of anion channels. It is predominantly expressed in the basolateral membrane of the retinal pigment epithelium. Studies show that bestrophin 1 functions as a Ca(2+)-dependent Cl(-) channel and modulator of voltage-dependent L-type Ca(2+) channels. It may also contribute to the basolateral cell conductance in airway epithelial cells. This protein is encoded by the VMD2 gene. Mutations in VMD2 can lead to different types of retinal or macular degenerations, including Best vitelliform macular dystrophy (BMD), autosomal recessive bestrophinopathy (ARB), autosomal dominant vitreoretinochoroidopathy (ADVIRC) and adult-onset vitelliform macular dystrophy (AVMD).
