BNIP3 Monoclonal antibody, PBS Only

BNIP3 Monoclonal Antibody for WB, IF/ICC, ELISA
Cat No. 68091-1-PBS
Clone No.2H7D8

Host / Isotype

Mouse / IgG2b

Reactivity

Human, Mouse

Applications

WB, IF/ICC, ELISA

BNIP3, NIP3

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

68091-1-PBS targets BNIP3 in WB, IF/ICC, ELISA applications and shows reactivity with Human, Mouse samples.

Tested Reactivity Human, Mouse
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen BNIP3 fusion protein Ag27935 Predict reactive species
Full Name BCL2/adenovirus E1B 19kDa interacting protein 3
Calculated Molecular Weight 194 aa, 22 kDa
Observed Molecular Weight25-30,50-60 kDa
GenBank Accession NumberBC009342
Gene Symbol BNIP3
Gene ID (NCBI) 664
RRIDAB_2918828
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ12983
Storage Buffer PBS only
Storage ConditionsStore at -80°C.

Background Information

BNIP3 (BCL2 interacting protein 3) is a member of the Bcl-2 family that is expressed in mitochondria and induces apoptosis (PMID: 10891486). It can regulate the permeabillity state of outer mitchondrial member (OMM), this regulation is accompanied by the formation of homo- and hetero-oligomers inside the membrane. Hypoxia can lead to transcriptional activation of BNIP3 through HIF-1α (PMID: 11559532). It's calculated molecule weight is 21.5 kDa. The antibody can detect bands around 25 and 50 kDa, representing monomeric and dimeric forms, respectively (PMID: 21364626).BNIP3 is related to the occurrence and development of tumors, cardiovascular diseases, and Parkinson's diseases.

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