- Featured Product
- KD/KO Validated
BDNF Polyclonal antibody, PBS Only
BDNF Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
WB, IF/ICC, Indirect ELISA
Conjugate
Unconjugated
Cat no : 25699-1-PBS
Synonyms
Validation Data Gallery
Product Information
25699-1-PBS targets BDNF in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | BDNF fusion protein Ag22489 |
Full Name | brain-derived neurotrophic factor |
Calculated Molecular Weight | 247 aa, 28 kDa |
Observed Molecular Weight | 30 kDa |
GenBank Accession Number | BC029795 |
Gene Symbol | BDNF |
Gene ID (NCBI) | 627 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
1) What is BDNF?
BDNF (brain-derived neurotrophic factor) is a small secreted growth factor that is important for the development and plasticity of the central nervous system and vital for long-term memory. Selected polymorphisms of BDNF have been shown to increase susceptibility to memory impairment and selected eating and mental disorders.
2) FAQs for BDNF
A) I can detect more than one band in my samples
BDNF is a neurotrophin that is a subject of maturation by proteolytic cleavage. The precursor protein (pre-proBDNF) is first cleaved to proBDNF (~34 kDa) by removing a signal peptide, and then to a mature form of BDNF (14 kDa). Additionally, (pre-)proBDNF can form dimers that run between 50 and 60 kDa, and a minor truncated form of proBDNF running at 28 kDa has also been reported (PMID: 11152678).