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BCAN Recombinant antibody, PBS Only

BCAN Uni-rAbTM Recombinant Antibody for Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Indirect ELISA

Conjugate

Unconjugated

CloneNo.

230126D6

Cat no : 82956-1-PBS

Synonyms

Brevican, CSPG7, Brevican core protein, Brain-enriched hyaluronan-binding protein, BEHAB

Validation Data Gallery

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  • Flow cytometry (FC) experiment of SH-SY5Y cells using BCAN Recombinant antibody (82956-1-RR)

    FC experiment of SH-SY5Y using 82956-1-RR (same clone as 82956-1-PBS)

    1x10^6 SH-SY5Y cells were intracellularly stained with 0.25 ug Anti-Human BCAN (82956-1-RR, Clone:230126D6) and APC-Conjugated Goat Anti-Rabbit IgG(H+L) at dilution 1:166 (red), or 0.25 ug Rabbit IgG control Rabbit PolyAb (30000-0-AP, Clone: ) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 82956-1-PBS in a different storage buffer formulation.

Product Information

82956-1-PBS targets BCAN in Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen BCAN fusion protein Ag13596
Full Name brevican
Calculated Molecular Weight 99 kDa
GenBank Accession NumberBC010571
Gene Symbol BCAN
Gene ID (NCBI) 63827
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Brevican is a brain-specific proteoglycan belonging to the aggrecan family that share a number of structural features. Brevican contains a hyaluronic acid-binding domain in its N-terminus and a lectin-like domain in its C-terminus. Expression of brevican is highly specific in the brain and increases as the brain develops. It may play a role in maintaining the extracellular environment of mature brain as a major constituent of the adult brain extracellular matrix (PMID:9117262). Brevican core protein exists as a 145 kDa full-length form and a 80 kDa N terminally truncated form (PMID: 8144512). This antibody can recognize the 72 kDa isoform of target.