BAK Polyclonal antibody

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BAK Polyclonal Antibody for ELISA

Cat No. 14673-1-AP

Publications(35)

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat and More (2)

Applications

WB, IHC, IF, ELISA

Synonyms

BAK1, Bcl-2 homologous antagonist/killer, Bcl2-L-7, Bcl-2-like protein 7, CDN1

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Published Applications

• WB: See 32 publications below
• IHC: See 2 publications below
• IF: See 1 publications below

Product Information

14673-1-AP targets BAK in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human, mouse, rat, chicken, sheep
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: BAK fusion protein Ag6354
• Full Name: BCL2-antagonist/killer 1
• Calculated Molecular Weight: 23 kDa
• GenBank Accession Number: BC004431
• Gene Symbol: BAK1
• Gene ID (NCBI): 578
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q16611
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

BAK1, also named as BAK, BCL2L7 and CDN1, belongs to the Bcl-2 family. In the presence of an appropriate stimulus, BAK1 accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. (PMID:17157251) BAK1 gene product primarily enhances apoptotic cell death following an appropriate stimulus. It can inhibit cell death in an Epstein-Barr virus-transformed cell line.

Publications

Species	Application	Title
human	WB	Cell Death Differ; ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity; Authors - Feng Xu
mouse	WB,IF	Nat Commun; Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA; Authors - Ayesha Sen
chicken	WB	Sci Total Environ; MitomiR-1736-3p regulates copper-induced mitochondrial pathway apoptosis by inhibiting AATF in chicken hepatocytes; Authors - Yuanxu Li
human	WB	Oncotarget; By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice.; Authors - Weiqi Dai
mouse	WB	Mol Ther Nucleic Acids; lncRNA MIRF Promotes Cardiac Apoptosis through the miR-26a-Bak1 Axis.; Authors - Xiaomin Su
mouse	WB	J Proteome Res; PPE38 of Mycobacterium marinum triggers the cross-talk of multiple pathways involved in the host response, as revealed by subcellular quantitative proteomics.; Authors - Wang Hui H