BAK Polyclonal antibody
BAK Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat and More (1)
Applications
WB, IHC
Conjugate
Unconjugated
Cat no : 14673-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| Sample-dependent, check data in validation data gallery | |
Published Applications
| WB | See 30 publications below |
| IHC | See 2 publications below |
Product Information
14673-1-AP targets BAK in WB, IHC applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse, rat, sheep |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | BAK fusion protein Ag6354 |
| Full Name | BCL2-antagonist/killer 1 |
| Calculated molecular weight | 23 kDa |
| GenBank accession number | BC004431 |
| Gene symbol | BAK1 |
| Gene ID (NCBI) | 578 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
BAK1, also named as BAK, BCL2L7 and CDN1, belongs to the Bcl-2 family. In the presence of an appropriate stimulus, BAK1 accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. (PMID:17157251) BAK1 gene product primarily enhances apoptotic cell death following an appropriate stimulus. It can inhibit cell death in an Epstein-Barr virus-transformed cell line.
Publications
| Species | Application | Title |
|---|---|---|
Biomed Pharmacother HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways. | ||
Target Oncol Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo. | ||
Genes Cancer Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells. | ||
Transplantation Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis. | ||
Mol Med Rep Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways. |
