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- KD/KO Validated
BAG6 Monoclonal antibody, PBS Only
BAG6 Monoclonal Antibody for WB, IHC, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, mouse, rat
Applications
WB, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1B8D3
Cat no : 66661-1-PBS
Synonyms
Validation Data Gallery
Product Information
66661-1-PBS targets BAG6 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.
Tested Reactivity | Human, mouse, rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | BAG6 fusion protein Ag24525 |
Full Name | HLA-B associated transcript 3 |
Calculated Molecular Weight | 119 kDa |
Observed Molecular Weight | 150-160 kDa |
GenBank Accession Number | BC003133 |
Gene Symbol | BAT3/BAG-6 |
Gene ID (NCBI) | 7917 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
BAT3 also known as Scythe or BAG6, is a nuclear protein implicated in the control of apoptosis and natural killer (NK) cell-dendritic cell (DC) interaction. BAT3 was first discovered as a member of a group of genes located within the class III region of the human major histocompatibility complex on chromosome 6, and has been extensively studied for its role in regulating apoptosis under various stress conditions such as DNA damage and endoplasmic reticulum-related stress. BAT3 has been shown to be required for p53 acetylation, which is critical for the enhancement of p53 transcriptional activity in response to DNA damage. In addition, BAT3 is involved in the regulation of development and reproduction of mammals by acting as a co-chaperone of the heat shock protein HSP70.