Product Information
68108-1-PBS targets AXL in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | AXL fusion protein Ag14401 Predict reactive species |
| Full Name | AXL receptor tyrosine kinase |
| Calculated Molecular Weight | 894 aa, 98 kDa |
| Observed Molecular Weight | 130-140 kDa |
| GenBank Accession Number | BC032229 |
| Gene Symbol | AXL |
| Gene ID (NCBI) | 558 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | P30530 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
Axl, also known as Ufo or Ark, is a receptor tyrosine kinase of the TAM (Tyro3, Axl and Mer) family. Axl is a single-pass type I membrane protein containing two fibronectin type-III domains, two Ig-like C2-type domains and one protein kinase domain. Axl mRNA is widely expressed with highest levels in the heart and skeletal muscle. Gas6 has been identified as a ligand for human Axl. Gas6/Axl signaling plays a role in cell survival, cell proliferation, migration and differentiation. It has been reported that 110-120 kDa non-glycosylated AXL protein can be detected(PMID: 31171001). Endogenous Axl is auto-phosphorylated and reacted with a tyrosine-phosphorylated protein of 140 kDa(PMID: 12730092).
