Product Information
66054-1-PBS targets ARHGDIB in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | ARHGDIB fusion protein Ag9091 Predict reactive species |
Full Name | Rho GDP dissociation inhibitor (GDI) beta |
Calculated Molecular Weight | 201 aa, 23 kDa |
Observed Molecular Weight | 27 kDa |
GenBank Accession Number | BC009200 |
Gene Symbol | ARHGDIB |
Gene ID (NCBI) | 397 |
RRID | AB_11045657 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | P52566 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
ARHGDIB, also known as RhoGDI2, is a conserved member of the RhoGDI family and plays an important role in cell migrations. It regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. It is mainly in hematopoietic, endothelial, and epithelial cells. It has been linked to tumorigenesis and metastasis. RhoGDI2 expression is downregulated in several cancer types, such as bladder, lung and lymphoma, but is upregulated in prostate and gastric cancer.