Product Information
66643-1-PBS targets ANLN in WB, IF/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | ANLN fusion protein Ag19294 Predict reactive species |
Full Name | anillin, actin binding protein |
Calculated Molecular Weight | 1124 aa, 124 kDa |
Observed Molecular Weight | 110 kDa~120 kDa |
GenBank Accession Number | BC034692 |
Gene Symbol | ANLN |
Gene ID (NCBI) | 54443 |
RRID | AB_2815000 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | Q9NQW6 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Anillin, an actin-binding protein, is a conserved cleavage furrow component important for cytokinesis. The human anillin protein localizes to the nucleus during interphase, the cortex following nuclear envelope breakdown, and the cleavage furrow during cytokinesis. It interactions with at least two other furrow proteins, actin and the septins through its C-terminal PH domain and N-terminal actin-binding domain. In anillin knockdown cells, the cleavage furrow ingressed but failed to complete the ingression. Anillin has been found to be overexpressed in tumors and may serve as promising marker for pancreatic carcinoma molecular diagnostics as well as a prognostic indicator for non-small cell lung cancers.