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ALK Monoclonal antibody, PBS Only

ALK Monoclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

7G9E3

Cat no : 60321-1-PBS

Synonyms

ALK, ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, TFG/ALK

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of human lymphoma tissue using ALK Monoclonal antibody (60321-1-Ig)

    IHC staining of human lymphoma using 60321-1-Ig (same clone as 60321-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human anaplastic large cell lymphoma (ALCL) tissue slide using 60321-1-Ig (ALK antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60321-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lymphoma tissue using ALK Monoclonal antibody (60321-1-Ig)

    IHC staining of human lymphoma using 60321-1-Ig (same clone as 60321-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human anaplastic large cell lymphoma (ALCL) tissue slide using 60321-1-Ig (ALK/CD246 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60321-1-PBS in a different storage buffer formulation.

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

60321-1-PBS targets ALK in IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen ALK fusion protein Ag21493
Full Name anaplastic lymphoma receptor tyrosine kinase
Calculated Molecular Weight 1620 aa, 176 kDa
GenBank Accession NumberNM_004304
Gene Symbol ALK
Gene ID (NCBI) 238
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570).