CoraLite®594-conjugated Angiotensinogen/AGT Monoclonal antibody

Angiotensinogen/AGT Monoclonal Antibody for
Cat No. CL594-68020
Clone No.1B2F5

Host / Isotype

Mouse / IgG2b

Reactivity

human, pig

Applications

AGT, Angiotensinogen, Serpin A8, SERPINA8, 1B2F5

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  {{ptg:cur_Conjugation}}
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

CL594-68020 targets Angiotensinogen/AGT in applications and shows reactivity with human, pig samples.

Tested Reactivity human, pig
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen Angiotensinogen/AGT fusion protein Ag16658 Predict reactive species
Full Name angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Calculated Molecular Weight 485 aa, 53 kDa
Observed Molecular Weight52 kDa
GenBank Accession NumberBC011519
Gene Symbol AGT
Gene ID (NCBI) 183
RRIDAB_2934793
Conjugate CoraLite®594 Fluorescent Dye
Excitation/Emission Maxima Wavelengths588 nm / 604 nm
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP01019
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene also have been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

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