FITC Plus Anti-Mouse NK1.1 (CD161) (PK136)
NK1.1 (CD161) Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG2a, kappa
Reactivity
mouse
Applications
FC
Conjugate
FITC Plus Fluorescent Dye
CloneNo.
PK136
Cat no : FITC-65138
Synonyms
Validation Data Gallery
Tested Applications
Positive FC detected in | mouse splenocytes |
Recommended dilution
Application | Dilution |
---|---|
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
FITC-65138 targets NK1.1 (CD161) in FC applications and shows reactivity with mouse samples.
Tested Reactivity | mouse |
Host / Isotype | Mouse / IgG2a, kappa |
Class | Monoclonal |
Type | Antibody |
Immunogen | NK-1+ cells from mouse spleen and bone marrow |
Full Name | killer cell lectin-like receptor subfamily B member 1A |
GenBank Accession Number | BC120707 |
Gene Symbol | NK1.1 |
Gene ID (NCBI) | 17057 |
RRID | AB_2883798 |
Conjugate | FITC Plus Fluorescent Dye |
Excitation/Emission Maxima Wavelengths | 495 nm / 524 nm |
Form | Liquid |
Purification Method | Affinity purification |
Storage Buffer | PBS with 0.09% sodium azide. |
Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
Background Information
NK1.1 (CD161), also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).
Protocols
Product Specific Protocols | |
---|---|
FC protocol for FITC Plus NK1.1 (CD161) antibody FITC-65138 | Download protocol |
Standard Protocols | |
---|---|
Click here to view our Standard Protocols |