Product Information
85065-3-PBS targets DDX46 as part of a matched antibody pair:
MP01807-1: 85065-3-PBS capture and 85065-1-PBS detection (validated in Cytometric bead array, Sandwich ELISA)
MP01807-2: 85065-3-PBS capture and 85065-2-PBS detection (validated in Cytometric bead array)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | DDX46 fusion protein Ag10342 Predict reactive species |
| Full Name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 |
| Calculated Molecular Weight | 1031 aa, 117 kDa |
| Observed Molecular Weight | 140 kDa |
| GenBank Accession Number | BC012304 |
| Gene Symbol | DDX46 |
| Gene ID (NCBI) | 9879 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q7L014 |
| Storage Buffer | PBS only , pH 7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
DDX46, also named as KIAA0801, is a 1031 amino acid protein, which belongs to the DEAD box helicase family. DDX46 has been shown to be required at the early step of pre-spliceosome assembly. It uses the energy released by the hydrolysis of ATP to rearrange local RNA-RNA or protein-RNA interactions. The nuclear DDX46 acted as a negative regulator of the antiviral innate response by recruiting the m6A'eraser' ALKBH5 to induce retention of antiviral innate mRNA in the nucleus.
