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  • Western Blot (WB) analysis of U-937 cells using KCNA3 Recombinant antibody (85049-4-RR)

    WB analysis of U-937 using 85049-4-RR

    U-937 cells were subjected to SDS PAGE followed by western blot with 85049-4-RR (KCNA3 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

  • Affinity and Kinetic Characterization of 85049-4-RR

    Affinity and Kinetic Characterization of 85049-4-RR

    Biolayer interferometry (BLl) kinetic assays of 85049-4-RR against Human KCNA3 were performed. The affinity constant is below 1 pM.

KCNA3 Recombinant antibody

KCNA3 {ptg:Brand} Recombinant Antibody for WB, ELISA
Cat No. 85049-4-RR
Clone No.242588H8

Review Product

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

Kv1.3, HUKIII, HPCN3, HLK3, HGK5

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

- +

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Tested Applications

Positive WB detected inU-937 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

85049-4-RR targets KCNA3 in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen KCNA3 fusion protein Ag5204 Predict reactive species
Full Name potassium voltage-gated channel, shaker-related subfamily, member 3
Calculated Molecular Weight 575 aa, 64 kDa
Observed Molecular Weight75 kDa
GenBank Accession NumberBC035059
Gene Symbol KCNA3
Gene ID (NCBI) 3738
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP22001
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Kv1.3 ( also known as KCNA3, MK3, HGK5, HLK3, PCN3, HPCN3) contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, which allows nerve cells to repolarize following an action potential efficiently. It plays an essential role in T cell proliferation and activation. Kv1.3 channels are expressed in various tissues and cell types including the brain, vascular smooth muscle cells, and leucocytes. Malfunction of Kv1.3 can alter the immune response, elicit neurotoxic effects or impact on cancer growth(PMID: 24305723; 24133455).

Protocols

Product Specific Protocols
WB protocol for KCNA3 antibody 85049-4-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols