TFPI Recombinant antibody, PBS Only (Detector)
TFPI Uni-rAbTM Recombinant Antibody for Cytometric bead array, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
Cytometric bead array, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
240977F12
Cat no : 83838-4-PBS
Synonyms
Validation Data Gallery
Product Information
83838-4-PBS targets TFPI as part of a matched antibody pair:
MP00812-3: 83838-1-PBS capture and 83838-4-PBS detection (validated in Cytometric bead array)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Fusion Protein |
| Full Name | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| Calculated Molecular Weight | 35 kDa |
| Observed Molecular Weight | 40-45 kDa |
| GenBank Accession Number | NM_006287.6 |
| Gene Symbol | TFPI |
| Gene ID (NCBI) | 7035 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
Tissue factor pathway inhibitor (TFPI) is a critical anticoagulant protein present in endothelium and platelets. TFPI is produced as two major isoforms in humans, TFPIa and TFPIb that result from alternative splicing. The TFPIb isoform localizes to the endothelium surface where it is a potent inhibitor of tissue factor-factor VIIa complexes that initiate blood coagulation. The TFPIa isoform is present in platelets. TFPI is a Kunitz-type serine protease inhibitor that exerts anticoagulant activity by blocking early procoagulant stimulia. TFPI can enhance anti-thrombotic treatment in sepsis, inflammatory diseases, and cardiovascular diseases.
