GATA3 Polyklonaler Antikörper

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• KD/KO Validated

GATA3 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ChIP, ELISA

Konjugation

Unkonjugiert

Publikationen

31

Kat-Nr. : 10417-1-AP

Synonyme

Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, GATA binding factor 3

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Galerie der Validierungsdaten

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  WB analysis using 10417-1-AP

  MCF-7 cells were subjected to SDS PAGE followed by western blot with 10417-1-AP (GATA3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 10417-1-AP

  T-47D cells were subjected to SDS PAGE followed by western blot with 10417-1-AP (GATA3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: MCF-7-Zellen, T-47D-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 2 publications below
• WB: See 21 publications below
• ChIP: See 1 publications below

Produktinformation

10417-1-AP bindet in WB, ChIP, ELISA GATA3 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: GATA3 fusion protein Ag0174
• Vollständiger Name: GATA binding protein 3
• Berechnetes Molekulargewicht: 443 aa, 48 kDa
• Beobachtetes Molekulargewicht: 37 kDa and 48 kDa
• GenBank-Zugangsnummer: BC003070
• Gene symbol: GATA3
• Gene ID (NCBI): 2625
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GATA3 is a transcriptional factor that binds to the enhancer elements of all 4 T-cell antigen receptor genes. GATA3 is highly expressed in naive, freshly activated cells and Th2 lineage cells and thought to be necessary and sufficient for Th2 cytokine gene expression. GATA3 and TBET interfer with each other to regulate gene expression. This is a rabbit polyclonal antibody raised against part of C-terminus of human GATA3.

Publikationen

Species	Application	Title
human		Cancer Cell; Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.; Authors - Keli Xu
		Cancer Res; Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.; Authors - Adams Jessica R JR
	WB	Oxid Med Cell Longev; Androgen Plays a Potential Novel Hormonal Therapeutic Role in Th17 Cells Predominant Neutrophilic Severe Asthma by Attenuating BECs Regulated Th17 Cells Differentiation via MBD2 Expression; Authors - Binaya Wasti
human	WB	Cell Death Dis; Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway.; Authors - Weiwei Sheng
human		Development; The inhibitor of histone acetyltransferases Nir regulates epidermis development.; Authors - Delphine Duteil
	WB	Int Immunopharmacol; Modulating Th1/Th2 drift in asthma-related immune inflammation by enhancing bone mesenchymal stem cell homing through targeted inhibition of the Notch1/Jagged1 signaling pathway; Authors - Wang Kun

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