• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human PDGFaa protein

Activity(Primary)

Typically ≤ 10 ng/mL

Species Reactivity

human,mouse,rat

Purity

>95%

Cat no : HZ-1215

Synonyms

PDGF 1, PDGF A, PDGF subunit A, PDGF1, PDGFA, PDGFaa



Technical Specifications

GeneID 5154
Species Human
Expression HEK293
Activity(Primary) Typically ≤ 10 ng/mL
Purity >95%
Endotoxin<1 EU/μg
Accession NumberP04085
Molecular Mass 19 and 26 reduced, 35, 40 and 45 kDa non-reduced, homodimer, glycosylated
Formulation 10 mM HOAc, See Certificate of Analysis for details
Species Reactivity human,mouse,rat

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 10 mM HOAc containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix.

Background

PDGFaa is a member of the platelet-derived growth factor family. Four members of this family are mitogenic factors for cells of mesenchymal origin, and they are characterized by a motif of eight cysteines. PDGFaa plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, and chemotaxis. It is also required for a normal lung alveolar septum formation during embryogenesis, development of the gastrointestinal tract, and spermatogenesis. PDGFaa is also involved in oligodendrocyte development and l myelination process in the spinal cord and cerebellum PMID: 29408302; 29282077; 27002148).

Synonyms

PDGF 1, PDGF A, PDGF subunit A, PDGF1, PDGFA, PDGFaa

Publications

SpeciesTitle
rat

Phytomedicine

Kaempferol attenuates carbon tetrachloride (CCl4)-induced hepatic fibrosis by promoting ASIC1a degradation and suppression of the ASIC1a-mediated ERS

Authors - Rui Cao
human

Oxid Med Cell Longev

Autophagy Contributes to the Maintenance of Genomic Integrity by Reducing Oxidative Stress.

Authors - Wenqing Bu
mouse

Stem Cell Reports

Conversion of Fibroblast into Functional Leydig-like Cell Using Defined Small Molecules.

Authors - Yan Yang
mouse

Front Cell Neurosci

Nicotinamide enhances myelin production after demyelination through reduction of astrogliosis and microgliosis

Authors - Stefanos Ioannis Kaplanis
human

Nat Biotechnol

Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain

Authors - Meiyan Wang