- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human Noggin protein
Activity(Primary)
1.5-15 ng/mL
Species Reactivity
human,mouse
Purity
>95%
Cat no : HZ-1118
Synonyms
NOG, noggin, SYM1, SYNS1
Validation Data Gallery
Technical Specifications
| GeneID | 9241 |
| Species | Human |
| Expression | HEK293 |
| Activity(Primary) | 1.5-15 ng/mL |
| Purity | >95% |
| Endotoxin | <1 EU/μg |
| Accession Number | Q13253 |
| Molecular Mass | 28 kDa reduced, 50 to 95 kDa non-reduced, homodimer, glycosylated |
| Formulation | 1x PBS, See Certificate of Analysis for details |
| Species Reactivity | human,mouse |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1xPBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix. |
Background
Noggin is an inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. It is essential for cartilage morphogenesis and joint formation. Noggin inhibits chondrocyte differentiation through its interaction with GDF5 and GDF6 (PMID: 29497255; 29167826; 29094227; 28842965).
Synonyms
NOG, noggin, SYM1, SYNS1
Publications
| Species | Title |
|---|---|
Cell Stem Cell Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability. | |
Nat Methods Long-term expansion of alveolar stem cells derived from human iPS cells in organoids. | |
Cell Stem Cell Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. | |
Nat Commun Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells | |
Biomaterials Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo. | |
Curr Biol Human-specific regulation of neural maturation identified by cross-primate transcriptomics |
Reviews
The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.
FH Lindsay (Verified Customer) (09-03-2024) | Recombinant human noggin is being used to generate tumouroids from patient tumour tissue. The cultures look successful and the supplier is one of the most competitively priced around. Would recommend.
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FH Lisa (Verified Customer) (08-11-2022) | The cytokine works well, with results comparable with the ones observed using the same product from other companies.
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