• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human FGF-9 protein

Activity(Primary)

2-11 ng/mL

Species Reactivity

monkey,human

Purity

>95%

Cat no : HZ-1329

Synonyms

Glia-activating factor (GAF) Heparin-binding growth factor 9 (HBGF-9) Fibroblast Growth Factor-9



Technical Specifications

GeneID 2254
Species Human
Expression HEK293
Activity(Primary) 2-11 ng/mL
Purity >95%
Endotoxin<1 EU/μg
Accession NumberP31371
Molecular Mass 25 kDa reduced and non-reduced, monomer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity monkey,human

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1x PBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix.

Background

FGF-9 is a 26 kdA, glycosylated protein that is a member of the FGF superfamily. It primarily binds with FGFR3 and plays prominent roles in the regulating embryonic, lung, and skeletal development. It is a key regulator of male sex determination through promoting the proliferation of pre-Sertoli cells. It signals in conjunction with FGF-10 and SHH to drive the development of the lung mesenchymal space. FGF-9 is also a positive regulator of chondrocyte proliferation and osteogenesis during the bone formation process. Overexpression of loss of FGF-9 during skeletal development often results in aberrant bone growth. (PMID: 28395336, 25772309, 16540513, 25435023).

Synonyms

Glia-activating factor (GAF) Heparin-binding growth factor 9 (HBGF-9) Fibroblast Growth Factor-9