ChromoTek anti-IL28a recombinant VHH, for 1x Cys conjugation

IL28Cys1 is an unconjugated recombinant anti IL28 Nanobody (VHH). Suitable for for dual cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.

Host/Type

Alpaca VHH

Reactivity

Human

Applications

Conjugation

Conjugate

Unconjugated

Cat no : IL28aCys1

Synonyms

IL-28a VHH, IL-28a single domain antibody (sdAb), Interferon Lambda 2, IFNL2, Cytokine Zcyto20

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Validation Data Gallery

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  BLI analysis of the interaction between varying concentrations of anti-IL-28A VHH and immobilised, biotinylated HumanKine IL-28A (HZ-1235). Fit indicates fitting of data to a 1:1 binding model.

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Product Information

IL28Cys1 is an unconjugated recombinant anti IL28 Nanobody (VHH). Suitable for for dual cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.

• Applications: Conjugation
• Reactivity: Human
• Conjugate: Unconjugated
• Type: Nanobody
• Class: Recombinant
• Host: Alpaca
• Affinity: 9 nM
• Molecular Weight: 15.0 kDa
• Form: Liquid
• RRID: AB_3665399
• Storage Buffer: 10 mM HEPES pH 7.0, 500 mM NaCl, 0.09% sodium azide
• Storage Condition: Store at -20°C
• Shipping: dry ice
• Background: IL28A, also named as IFNL2 and ZCYT020, is a cytokine with immunomodulatory activity. It up-regulates MHC class I antigen expression. IL28A is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. It plays a significant role in the antiviral immune defense in the intestinal epithelium.